Former Graduate Students

Joseph Verry, BS

MD Ph.D. student (May 2024 – Aug 2024)
Medical Scientist Training Programs (MSTP) UC College of Medicine

Joseph received his Bachelor of Science in Engineering in Biomedical Engineering from the University of Iowa in Spring 2022. He then joined the University of Cincinnati Medical Scientist Training Program in Fall 2022 to complete his MD-PhD training. His long-term goal is to diagnose and treat cardiovascular diseases using state-of-the-art technologies. His PhD thesis was focused on defining the presence of tissue-specific inflammation and neutrophil extracellular traps in hypertrophic cardiomyopathy. Due to the relocation of the lab to the University of Arizona in Tucson, AZ, he had to transfer to the lab in order to continue his PhD thesis work.

Darshini Desai, MS

Graduate Student (Aug 2018 – May 2024)

Darshini Desai  received her Bachelor’s in Pharmacy in Aug 2015 from Mumbai University in India and Master of Science in Pharmacology in May 2018 from Auburn University in Auburn, AL. She joined the PhD program at University of Cincinnati in August 2018 under the mentorship of Dr. Sadayappan. Hypertrophic cardiomyopathy (HCM) is a genetic disorder affecting many worldwide. Prevalence of people suffering from HCM in the United States itself is 600,000 and is on the rise. HCM is characterized by the thickening of the heart muscle which causes left ventricular hypertrophy and can lead to sudden cardiac death, especially in young adults. Mutations in the genes that encode for sarcomeric proteins are usually involved in causing cardiac disorders like HCM. One such mutation in MYBPC3, a cardiac isoform of myosin binding protein C encodes a sarcomeric protein (cMyBP-C) that is involved in maintaining sarcomeric stability and regulating cardiac contractility. Darshini’s PhD thesis worked on determining the pathogenesis of cMyBP-C gene variants, prevalent in the South Asian population, progressing to HCM. Using human cardiac organoids, she investigated the involvement of secondary risk factors, such as pressure overload, diabetes, etc, that aggravate the disease phenotype. Her studies are supported by the American Heart Association predoctoral training fellowship (20PRE35120272). Her PhD thesis committee members included Drs. Litsa Kranias, Richard Becker, Jo El Schultz and Yi- Gang Wang. Currently, she is a postdoctoral fellow at Icahn School of Medicine Mount Sinai, New York.

Mohit Kumar, MS, PhD

Graduate Student ( May 2016-Jun 2020 )

Dr. Kumar received his Master of Science in Molecular Biophysics and Biochemistry in August 2011 from the Illinois Institute of Technology in Chicago, IL. After four years of research experience in academia, focused on cardiac physiology at Loyola University Chicago, Mohit joined the PhD program at the University of Cincinnati in 2016 under the mentorship of Dr. Sadayappan in the Molecular, Cellular, and Biochemical Pharmacology program. His PhD studies focused on determining the role of cMyBP-C phosphorylation in calcium handling and cMyBP-C structure and function in the heart. He was funded by the American Heart Association predoctoral training fellowship to support his PhD thesis studies (17PRE33630192). Under the mentorship of Dr. Sadayappan at University of Cincinnati, his PhD thesis committee members included Drs. Litsa Kranias, John R. Lorenz, Douglas Millay and Terry L. Kirley. He has expertise in biophysical techniques measuring contractility at the sarcomere, muscle, and cardiac levels. Currently, he is a senior scientist at Regeneron, a Biotechnology company headquartered in Westchester County, New York.

Thomas L. Lynch, IV, PhD

Graduate student (December 2012 – September 2016)

Dr. Lynch received his Bachelor of Science in Biology in May 2011 from Lewis University in Romeoville, Illinois where he conducted undergraduate research in microbiology. He then joined the Molecular Pharmacology and Therapeutics graduate program at Loyola University Chicago in August of 2011 and was under the mentorship of Dr. Sadayappan beginning in December 2012. His work in the lab focused on determining whether circulating cardiac myosin binding protein-C is immunogenic following myocardial infarction producing auto-antibodies that cause cardiac inflammation and heart failure. He has published several first authored papers (Proteomics Clin Appl. 2014, Oxid Med Cell Longev. 2015, J Mol Cell Cardiol. 2017, JACC Basic Transl Sci, 2017). His PhD thesis committee members included Drs. Pieter de Tombe, R. John Solaro, Adriano Marchese and Xun Ai. In support of his work, Dr. Lynch was awarded a pre-doctoral fellowship grant from the American Heart Association (15PRE22430028). After a brief postdoctoral training at University of Wisconsin in Madison, WI, and Loyola University Chicago, Maywood, IL, he has been working as a Senior Scientist I, Drug Metabolism, DMPK-BA, Abbvie, North Chicago, IL.

Brian Lin, PhD

Graduate student (December 2011 – June 2016)

Dr. Lin received his undergraduate degree in Biology/Zoology in May 2008. Upon graduation, he worked at Cincinnati Children’s Hospital with Dr. Charles Vorhees, focusing primarily on behavioral neuroscience research. He continued his work in behavioral neuroscience at Northwestern University as a Research Assistant to Dr. Aryeh Routtenberg from June 2009 to October 2010. His primary studies focused on post-translational modifications during learning and memory. Dr. Lin did his PhD studies at Loyola University Chicago. His thesis committee consisted of Drs. Pieter de Tombe, Elizabeth McNally, Xun Ai and Renzhi Han. He was under the mentorship of Dr. Sadayappan in the Department of Cell and Molecular Physiology from December 2011 until June 2016. His research work in the lab was entirely focused on characterizing the distribution, regulation and function of fast skeletal myosin binding protein-C in skeletal muscle and cardiac muscle in health and disease. Brian then completed his postdoctoral studies with Dr. David Kass at Johns Hopkins, Baltimore, MD. Currently, he is an Assistant Professor (tenure-track) at the Medical College of Wisconsin, Milwaukee, WI 53226.

David Barefield, PhD

Graduate student (September 2009 – June 2014)

Dr. Barefield received his undergraduate degree in Biology and Biochemistry in May 2009 from Augustana College in Rock Island, Illinois. He joined the Cell and Molecular Physiology graduate program at Loyola University Chicago in August of that year. Dave’s work in the lab focused on developing in vivo models of cardiovascular disease to determine how cardiac genetic defects worsen the development of heart disease. In support of his work, Dr. Barefield was awarded a pre-doctoral fellowship grant from the American Heart Association (11PRE7240022). He had Drs. Pieter de Tombe, Christine Seidman, Kyle Henderson and Kenneth Byron in his thesis committee. Dave’s work in the lab generated data for a variety of projects using mouse models of cardiovascular disease, which resulted in numerous publications. Following the completion of his PhD in June 2014 with Dr. Sadayappan, Dave joined Dr. Elizabeth McNally’s lab at University of Chicago, Chicago, IL for his postdoctoral studies. With the NIH K99/R00 funding support, he moved back to Loyola University Chicago and started his independent research group.

For queries and opportunities, Please Contact :

Sakthivel Sadayappan, PhD, MBA, FAHA
Professor and Head
Department of Cellular & Molecular Medicine
Associate Director, Sarver Heart Center
Czarina M. & Humberto S. Lopez Chair for Excellence in Cardiovascular Research
University of Arizona College of Medicine
Tucson, AZ 85724-5217, USA

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